Smart Assistive Technology for People with Visual Field Loss

Visual field loss results in the lack of ability to clearly see objects in the surrounding environment, which affects the ability to determine potential hazards. In visual field loss, parts of the visual field are impaired to varying degrees, while other parts may remain healthy. This defect can be debilitating, making daily life activities very stressful. Unlike blind people, people with visual field loss retain some functional vision. It would be beneficial to intelligently augment this vision by adding computer-generated information to increase the users' awareness of possible hazards by providing early notifications. This thesis introduces a smart hazard attention system to help visual field impaired people with their navigation using smart glasses and a real-time hazard classification system. This takes the form of a novel, customised, machine learning-based hazard classification system that can be integrated into wearable assistive technology such as smart glasses. The proposed solution provides early notifications based on (1) the visual status of the user and (2) the motion status of the detected object. The presented technology can detect multiple objects at the same time and classify them into different hazard types. The system design in this work consists of four modules: (1) a deep learning-based object detector to recognise static and moving objects in real-time, (2) a Kalman Filter-based multi-object tracker to track the detected objects over time to determine their motion model, (3) a Neural Network-based classifier to determine the level of danger for each hazard using its motion features extracted while the object is in the user's field of vision, and (4) a feedback generation module to translate the hazard level into a smart notification to increase user's cognitive perception using the healthy vision within the visual field. For qualitative system testing, normal and personalised defected vision models were implemented. The personalised defected vision model was created to synthesise the visual function for the people with visual field defects. Actual central and full-field test results were used to create a personalised model that is used in the feedback generation stage of this system, where the visual notifications are displayed in the user's healthy visual area. The proposed solution will enhance the quality of life for people suffering from visual field loss conditions. This non-intrusive, wearable hazard detection technology can provide obstacle avoidance solution, and prevent falls and collisions early with minimal information

PVPF Tool: An Automated Web Application for Real-Time Photovoltaic Power Forecasting

In this paper, we propose a fully automated machine learning based forecasting system, called Photovoltaic Power Forecasting (PVPF) tool, that applies optimized neural networks algorithms to real-time weather data to provide 24 hours ahead forecasts for the power production of solar photovoltaic systems installed within the same region. This system imports the real-time temperature and global solar irradiance records from the ASU weather station and associates these records with the available solar PV production measurements to provide the proper inputs for the pre-trained machine learning system along with the records' time with respect to the current year. The machine learning system was pre-trained and optimized based on the Bayesian Regularization (BR) algorithm, as described in our previous research, and used to predict the solar power PV production for the next 24 hours using weather data of the last five consecutive days. Hourly predictions are provided as a power/time curve and published in real-time at the website of the renewable energy center (REC) of Applied Science Private University (ASU). It is believed that the forecasts provided by the PVPF tool can be helpful for energy management and control systems and will be used widely for the future research activities at REC

Solar Photovoltaic Power Forecasting in Jordan using Artificial Neural Networks

In this paper, Artificial Neural Networks (ANNs) are used to study the correlations between solar irradiance and solar photovoltaic (PV) output power which can be used for the development of a real-time prediction model to predict the next day produced power. Solar irradiance records were measured by ASU weather station located on the campus of Applied Science Private University (ASU), Amman, Jordan and the solar PV power outputs were extracted from the installed 264KWp power plant at the university. Intensive training experiments were carried out on 19249 records of data to find the optimum NN configurations and the testing results show excellent overall performance in the prediction of next 24 hours output power in KW reaching a Root Mean Square Error (RMSE) value of 0.0721. This research shows that machine learning algorithms hold some promise for the prediction of power production based on various weather conditions and measures which help in the management of energy flows and the optimisation of integrating PV plants into power systems.</jats:p

A Smart Context-Aware Hazard Attention System to Help People with Peripheral Vision Loss

Peripheral vision loss results in the inability to detect objects in the peripheral visual field which affects the ability to evaluate and avoid potential hazards. A different number of assistive navigation systems have been developed to help people with vision impairments using wearable and portable devices. Most of these systems are designed to search for obstacles and provide safe navigation paths for visually impaired people without any prioritisation of the degree of danger for each hazard. This paper presents a new context-aware hybrid (indoor/outdoor) hazard classification assistive technology to help people with peripheral vision loss in their navigation using computer-enabled smart glasses equipped with a wide-angle camera. Our proposed system augments users&#8217; existing healthy vision with suitable, meaningful and smart notifications to attract the user&#8217;s attention to possible obstructions or hazards in their peripheral field of view. A deep learning object detector is implemented to recognise static and moving objects in real time. After detecting the objects, a Kalman Filter multi-object tracker is used to track these objects over time to determine the motion model. For each tracked object, its motion model represents its way of moving around the user. Motion features are extracted while the object is still in the user&#8217;s field of vision. These features are then used to quantify the danger using five predefined hazard classes using a neural network-based classifier. The classification performance is tested on both publicly available and private datasets and the system shows promising results with up to 90% True Positive Rate (TPR) associated with as low as 7% False Positive Rate (FPR), 13% False Negative Rate (FNR) and an average testing Mean Square Error (MSE) of 8.8%. The provided hazard type is then translated into a smart notification to increase the user&#8217;s cognitive perception using the healthy vision within the visual field. A participant study was conducted with a group of patients with different visual field defects to explore their feedback about the proposed system and the notification generation stage. The real-world outdoor evaluation of human subjects is planned to be performed in our near future work

Transcriptional modulator ZBED6 affects cell cycle and growth of human colorectal cancer cells

The transcription factor ZBED6 (zinc finger, BED-type containing 6) is a repressor of IGF2 whose action impacts development, cell proliferation, and growth in placental mammals. In human colorectal cancers, IGF2 overexpression is mutually exclusive with somatic mutations in PI3K signaling components, providing genetic evidence for a role in the PI3K pathway. To understand the role of ZBED6 in tumorigenesis, we engineered and validated somatic cell ZBED6 knock-outs in the human colorectal cancer cell lines RKO and HCT116. Ablation of ZBED6 affected the cell cycle and led to increased growth rate in RKO cells but reduced growth in HCT116 cells. This striking difference was reflected in the transcriptome analyses, which revealed enrichment of cell-cycle–related processes among differentially expressed genes in both cell lines, but the direction of change often differed between the cell lines. ChIP sequencing analyses displayed enrichment of ZBED6 binding at genes up-regulated in ZBED6-knockout clones, consistent with the view that ZBED6 modulates gene expression primarily by repressing transcription. Ten differentially expressed genes were identified as putative direct gene targets, and their down-regulation by ZBED6 was validated experimentally. Eight of these genes were linked to the Wnt, Hippo, TGF-β, EGF receptor, or PI3K pathways, all involved in colorectal cancer development. The results of this study show that the effect of ZBED6 on tumor development depends on the genetic background and the transcriptional state of its target genes